KEIFEI Mechano Growth Factor (MGF)

Mechano growth factor (MGF)     

Presentation: Each 2ml multidoses vial contains 2mg/vial. With Keifei® wording imprinted on the side. Greenish blue colour cap with keifei® wording stamp on it. Come in both 3 x 2mg/vial with 3 x 2ml/ampoules of Bacteriostatic Water in a plastic insert in white and blue colour box. 1 set of 10 digits authentication codes paste on the plastic tray.

Mechano growth factor (MGF) is a novel splice variant of the Insulin-Like Growth Factor-1 (IGF-1), also known as IGF-1 Ec in humans and IGF-1Eb in rodents. It is actually originally called MGF because the RNA form of it is expressed in muscle tissues in response to the overload or/and damage of muscle growth tissue. The C-terminal peptide of the mechano growth factor (MGF) is a crucial region for the alternative splicing of the peptide. The alternative splicing in the MGF is brought about by the shift in the reading frame in which a specific C-terminal sequence (E-domain) is encoded by exon 5 and the first part of the exon 6. Another interesting point in MGF is that, because of the E domain it contains, MGF can act on muscles independently from the rest of the molecule. Furthermore, MGF can elicit very different effects with mGF promoting satellite cells proliferation and IGF-1 inducing differentiation